Prazosin is a synthetic piperazine derivative and an alpha-1 adrenergic receptor inhibitor used primarily as an anti-hypertensive. Prazosin's effects are most pronounced in the large resistance vessels (i.e. arterioles) and result in a decrease in total systemic vascular resistance (SVR) without a rebound or reflex geptsite.infoal Names: Prazosin; Furazosin; Prazosin hydrochloride | C19H22ClN5O4 | CID - structure, chemical names, physical and chemical properties, classification, patents, literature, biological Soluble at ambient temperatures (mg/ml): acetone, ; methanol, ; ethanol, ; dimethylformamide, ; dimethylacetamide, ; chloroform, Molecular Formula: C19H22ClN5O4.
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A stock solution may be made by dissolving the prazosin. (hydrochloride) in the solvent of choice. Prazosin (hydrochloride) is soluble in DMSO at a concentration of approximately. mg/ml. Prazosin (hydrochloride) is sparingly soluble in aqueous solutions. To enhance aqueous solubility, dilute the. Prazosin hydrochloride is an adrenergic α1-adrenoceptor, α2B-AR (α2B-adrenoceptor) and a potent melatonin MT3 receptor antagonist. A study investigated the putative inhibitory effect of prazosin on changes evoked by a NMDA receptor antagonist, MK within the Syrian hamster hypothalamus.
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