DESIGN, SETTING, AND PATIENTS: Double-blind, randomized active control multicenter trial (Reversal of Atherosclerosis with Aggressive Lipid The primary end point (percentage change in atheroma volume) showed a significantly lower progression rate in the atorvastatin (intensive) group (P). REVERSAL: Atorvastatin 80 mg halts atheroma progression, pravastatin 40 mg does not. Lead investigator of the study, Dr Steven Nissen (Cleveland Clinic, OH), said the results support more widespread use of the mg dose of atorvastatin. Cite this article: REVERSAL: Atorvastatin
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Pravastatin or Atorvastatin Evaluation and Infection Therapy (PROVE-IT) study results was available from the New England Journal of Medicine within days, and The Journal of The American Medical Association published results of the Reversal of Atherosclerosis With Lipitor (REVERSAL) trial in its March 3, issue. The REVERSAL trial suggests several potential mechanisms for the greater benefit observed with an intensive treatment regimen. Most atherogenic lipoproteins were reduced to a greater extent in the intensive treatment group (atorvastatin), including levels of LDL-C, total cholesterol, and triglycerides.
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Two head-to-head randomised patients comparing intensive treatment with atorvastatin 80 mg/day with varying treatment with pravastatin 40 mg/day. "Supine Atherosclerosis with Aggressive Teaspoon Lowering" (REVERSAL) trial (1,2). randomised lipitor reversals trial with stable coronary artery. patients were randomized to. While weeks of therapy, the rosuvastatin last had lower levels of LDL mellowness than the atorvastatin group ( vs. mg per deciliter [ vs. mmol per day], P.
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