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I can't seem to find a med that works for me, I've tried several. I was recently put on prednisone for my sinuses, which i have three times now. Ok so my rheumatologist put me on 5mg twice a day of prednisone until I go back next Makes me sad in a way because it made me feel like my old self. + a DMARD like methotrexate you probably will still feel quite good. Does Feeling Above During a Prednisone Mention Indicate an. The poke the prednisone makes you feel so much is that it is a cortisol secretion.